If you are really concerned about going the extra mile to protect your luggage, there are some things you can do.
You could purchase baggage insurance. Be sure to check to see what is covered.
You could purchased Excess Valuation from your airline.
You could wrap your luggage at the airport. A TSA agent may cut through the wrap if they need to open your bag.
You could ship your luggage to your destination or back home. This could be a better option, especially if you have breakable items.
You could pack some duct tape. It comes in handy if you need to repair a broken zipper, a rip in your bag, or a torn handle. Did you know you can buy a travel size roll of duct tape so you don’t have to bring the whole heavy roll? Or, wrap some around a straw if you don’t need a whole bunch.